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Development is challenging to study because it is a period of very rapid change in cell number, cell location and cell structure. Classically, images of developing embryos were done with time time-lapse photography. This visualized gross changes as seen in the movie below of a zebra fish embryo developing from the lab of Philipp Keller, at European Molecular Biology Laboratory (EMBL), Germany.
HHMI recently published an article about a new microscope technique for watching cells in embryos divide and move. This does not reveal chemical changes in individual cells, but it does permit finer mapping of individual embryonic cells as they divide mitotically and migrate during periods of differentiation. See the movie below; again from Keller's lab.
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